Moreover, MGBG pretreatment in the ACTD-treated HeLa, A549, and MCF7 cells markedly diplayed c-myc gene expression by 0.43, 0.41 and 0.49 fold in the presence of 3 μM ACTD, respectively, suggesting that depletion of the intracellular polyamine content increased the inhibitory activity of ACTD on the c-myc gene expression in cancer cells. Here, MYC is linked to cancer.