Moreover, ICAM-3 has been identified in early stages of vascular proliferation [53], shown to be inversely correlated with the level of vascular differentiation in infantile hemangiomas [55] and that it contributes to the control of the integrity of human bone marrow endothelial layers, likely via an association with an ERM protein moesin and production of reactive oxygen synthase [57]. This evidence concerns the gene ICAM3 and capillary hemangioma.