TCF7L2 and cancer: For example, genetic susceptibility alleles of CRC (Colorectal Cancer) were identified by the significant enrichment of GWAS SNPs in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway [16]; also, the discovery of TCF7L2 (Transcription Factor 7-Like 2), a human type 2 diabetes and cancer related genetic locus, was primarily driven by identifying the overrepresentation of significantly associated loci within 5 kb region of the target gene [17].