In addition to these cancer-associated annotations, 12 genes (BCL2, BRCA1, CCND1, ESR1, ESR2, FOS, IL1B, KRAS, PTEN, PTGS2, STAT3, TNF) were enriched for “response to steroid hormone stimulus” (FDR-adjusted p-value = 7.3×10−6). This evidence concerns the gene ESR1 and cancer.