Three patients, one with diabetes mellitus, one with kidney failure and one with HIV, responded with lower levels of the Th1- pro-inflammatory cytokines/chemokines, and a liver transplanted patient only responded with IP-10 (175 pg/μl) and IL-2 (6 pg/μl), just above each cut-off, after ESAT-6 stimulation. The gene discussed is IL2; the disease is diabetes mellitus.