Oral administration of transgenic rice containing the major mouse T-cell epitopes derived from Cry j 1 and Cry j 2 [13] or 7crp [14] resulted in inhibition of the allergy-associated Th2 reactions such as decreased total and allergen-specific IgE levels, change in cytokine production profiles, and a reduction in sneezing. The gene discussed is IGHE; the disease is allergic disease.