While, as previously reported, we observed a decreased IL-10 production in T cells from MS patients, addition of calcitriol could restore the overall IL-10:IFNγ ratio, by maintaining the IL-10 levels (which are lowered in healthy controls and correlated with the reduced proliferation observed with calcitriol) and by promoting a further decrease in IFNγ production. The gene discussed is IL10; the disease is myeloid sarcoma.