Only one gene in this 29-gene subset, Enpp2, showed a U-shaped response to increasing E2 concentrations; Enpp2 codes for autoaxin, an ecto-enzyme responsible for producing lysophophatidic acid (LPA), known to be a mitogen for both ovarian and prostate cancer cells, which stimulates cell proliferation, survival and migration (reviewed in [45]). The gene discussed is ENPP2; the disease is prostate cancer.