In addition, the HLA-A2.1, HLA-B7 and HLA-B35 haplotype associated PfCSP CD8+ T-cell epitopes have all been associated with protection from malaria in Africans and other ethnic groups [29]–[32] thus a vaccine based on these CD8+ T-cell epitopes should have a broad coverage throughout the world. This evidence concerns the gene CD8A and malaria.