SH2D2A and neoplasm: Since we did not observe any major effect of SH2D2A on the in vitro responses of naïve TCR-transgenic CD4+ T cells (Figure 4C and D), while there clearly was a difference in tumor protection (Figure 5B), we examined whether presence of SH2D2A affected the in vitro response of TCR-transgenic CD4+ T from tumor-experienced mice.