F8 and hemophilia A: Given our previous work linking the functional characteristics of anti-fVIII antibodies to their fVIII epitope, we analyzed the thrombin generation response in the context of fVIII and/or rfVIIa supplementation in severe hemophilia A plasma spiked with a panel of these biochemically-defined, non-overlapping murine MAbs spanning the A and C domains of fVIII.