Syndecan-1 driven upregulation of serglycin (the only constitutively intracellular proteoglycan) in mesothelioma cells can be an important new finding for cancer cell biology, as there are only a few reports linking serglycin to tumors, mostly to multiple myeloma [98] and nasopharyngeal carcinoma cells [99]. The gene discussed is SDC1; the disease is cancer.