To address these, we have calculated IR status, assessed for mesenchymal phenotype and proliferation rate, studied the gene expression profile in BM-MSCs to mark the disease memory depicting obesity, IGT with IR including the inflammatory status, and finally we have examined for differentiation/functional capabilities of BM-MSCs to form mature adipocytes and Insulin-like cellular aggregates (ILCAs). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.