In similar lines, the observed increase in adipocyte formation among BM-MSCs (Mutant) vis-à-vis with an increased expression of IL-6 and TNFα (pro-inflammatory adipokine) underline for visceral fat accumulation [39] in these Mutant rats as compared to its Lean and Control [19] and correlate positively with obesity, IR and IGT. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.