The Von Hippel-Lindau (VHL) tumor suppressor gene is themost prominent gene that is frequently inactivated in renal cancers and mutations inthis gene have been associated with the development of sporadic clear cell renalcarcinomas [45].We analyzed if the mutation status of genes commonly mutated in renal cancer cellscorrelates with the sensitivity of these cells to englerin A. The somatic mutationswe compared affected the genes VHL, CDK2NA,PTEN, TP53, NF2 and SETD2(Fig. 6). This evidence concerns the gene PTEN and renal carcinoma.