In human renal cell carcinomas in particular twopotassium ion channels of the ether-a-go-go (EAG) family were reported to beup-regulated [41].An additional possible target is CXCR4, a C-X-C chemokine receptor that has beenreported by multiple groups to be up-regulated in renal cancers [42]. This evidence concerns the gene CXCR4 and hereditary clear cell renal cell carcinoma.