Indeed, a role of the AT2 receptor in cardiac hypertrophy has been described that may involve the activation and subsequent accumulation of promyelocytic zinc finger protein (PLZF) in the perinuclear region of the cardiomyocyte, thereby inducing the expression of p85a PI3K followed by activation of p70S6 kinase and the development of cellular hypertrophy [25]. This evidence concerns the gene ZBTB16 and cardiac hypertrophy.