ADCY1 and Acidosis: Furthermore, heterozygosity for the rs2230739 SNP in the ADCY9 gene, encoding an adenylate cyclase, was associated with a 50% reduction in the risk of acidosis (AG vs. AA/GG, OR = 0.516, 95% CI 0.302–0.882, p = 0.0129) (Table 2, Figure 2).