Two mutations in the G6PD gene on the X chromosome (202: rs1050828 CT vs. other and 376: rs1050829 CT vs. other) were strongly associated with protection from severe malaria, and with protection from each of the different clinical phenotypes of severe malaria, in heterozygous females (OR = 0.3–0.5; p<0.05–p<8e-6) but not in hemizygous males (Table 2). This evidence concerns the gene G6PD and malaria.