An adenosine A2a receptor (CGS-21680), an angiotensin II receptor-like 1 agonist (angiotensin II) and a purinergic receptor P2Y G-protein coupled 2 agonist (2-(methylthio) adenosine 5′-triphosphate tetrasodium salt hydrate), which were all agonists of up-regulated GPCRs in the microarray list, had no effect on tumor cell growth. This evidence concerns the gene P2RY2 and neoplasm.