Under hypoxic condition HIF-1 coordinates the expression of many genes that orchestrate angiogenesis and cancer cell metabolism reprogramming, including GLUT1 and GLUT3, glycolytic enzymes, vascular endothelial growth factor (VEGF), erythropoietin (EPO), heme oxygenase-1 (HO-1), etc [11]. The gene discussed is HMOX1; the disease is cancer.