HIF-1 has already been proposed as a key player of cancer cells survival, and mechanisms proposed are mainly correlated to its ability to prompt anaerobic glycolitic metabolism, or expression of anti-apoptotic proteins, as Bcl-2, Bcl-XL or down regulation of pro-apoptotic proteins such as Bid or Bax [29], [30]. The gene discussed is BCL2L1; the disease is cancer.