To test the biological significance of the interaction between H2A.Z nucleosomes and Brd2, we examined their relationship in the context of androgen receptor (AR)- regulated genes since we and others have previously reported that H2A.Z is required for the full activation of AR-regulated genes in the prostate cancer cell line LNCaP [15], [61]. This evidence concerns the gene BRD2 and Familial prostate cancer.