Notably, Mtb peptide stimulation led to ∼10%(∼12%) and ∼1%(∼1.2%) more increases in cytokine-producing cells in Tim-3HighCD4+(or CD8+) T-cell subset in active TB and LTBI, respectively, when compared to the culture without peptide stimulation (Figure 2, Figure S5, Figure S6), These results suggested that the at least some of Tim-3+ T-cell effector cells were Mtb-specific. The gene discussed is HAVCR2; the disease is tuberculosis.