The mean percentages of Tim-3-expressing CD4+ (or CD8+) T cells in PBMC of active TB disease and LTBI after Mtb peptide stimulation were increased approximately 9.3% and 3.0% (or 8.9% and 2.8%) more than those without Mtb peptide stimulation, respectively (Figure 1).These results suggested that active TB up-regulated Tim-3 and drove increases in numbers of Tim-3+CD4+ and CD8+ T cells. This evidence concerns the gene CD8A and tuberculosis.