Interestingly, only ≤2.2% and ≤3.5% cells in Tim-3HighCD4+(or CD8+) T cells from subjects with LTBI were able to produce cytokines in the absence and presence of Mtb peptide, respectively (Figure 2D,E,F, Figure S5, and Figure S6), implicating that TB inflammation or disease course contributed to large increase in Tim-3High T effector cells actively producing cytokines. The gene discussed is CD8A; the disease is tuberculosis.