HAVCR2 and tuberculosis: The ability of Tim-3+ T cells to spontaneously produce cytokines in active TB appears to consist with our recent observation that active Mtb infection, but not SIV/SHIV infection or control setting, allows for intracellular cytokine staining (ICS) detection of cytokine production by T cells without the need for ex vivo stimulation with Mtb antigens [32], [33], [34].