The current study demonstrates that Tim-3-expressing CD4+ T cells not only can produce Th1 cytokines(IFN-γ, IL-2), but also produce appreciable amounts of IL-22, IL-4 (data not shown), and IL-17A (data not shown), suggesting that Tim-3High CD4+ T-cell subset in active TB are capable to differentiate into Th1, Th2, Th22/Th17 cells. The gene discussed is IL4; the disease is tuberculosis.