FOXP3 and amyotrophic lateral sclerosis: As shown by Kaplan–Meier curves indicating percent survival of ALS patients to 100 AALS points over time, 66% of patients with FoxP3 levels below the ROC cutoff were above 100 AALS points at the end of the 3.5 years, while only 36.7% of patients with FoxP3 levels above the ROC cutoff were above 100 AALS points (p = 0.0072; Fig 9A).