We previously reported relatively high expression of βII- and βIII-tubulin in vascular endothelial cells [40] and showed that both these tubulin isotypes strongly influence the response of non-small cell lung carcinoma cells (NSCLC) to chemotherapeutic drugs [25, 28, 29, 41]. The gene discussed is CACNA1E; the disease is non-small cell lung carcinoma.