Although ALS was not an enriched functional category, there was upregulation in OM neurons of the expression of a number of genes in which mutations are known to cause motor neuron degeneration, including C9ORF72 (FC 2.56, q = 4.0E−6), BSCL2 (FC 3.09, q = 0.003), optineurin (FC 2.0, q = 0.001), spastin (FC 2.4, q = 2.95E−6), and VAPB (FC 1.8, q = 1.0E−5). Here, SPAST is linked to Motor neuron atrophy.