AGT and hypertensive disorder: For example, increased reactive oxygen species (ROS), including superoxide (O2•−), hydroxyl (OH•) and peroxyl radicals (ROO•) or hydrogen peroxide (H2O2), formation precedes the development of hypertension in spontaneously hypertensive rats (SHR) and in angiotensin II (Ang II)-infused mice [10,11,12,13].