Similarly, when RIP-GP mice were crossed with WAS KO mice, the incidence of overt diabetes after LCMV challenge was significantly reduced compared with that seen in RIP-GP single transgenic animals (Fig 2, C), although not to the extent seen in bone marrow chimeric mice, which is probably due to the additional immunosuppressive effects of irradiation and bone marrow transplantation. Here, WAS is linked to diabetes mellitus.