In the pancreatic adenocarcinoma cohort calpain-1 had a median H-score of 140 and ranged from 0 to 280; calpain-2 had a median H-score of 118 and ranged from 10 to 293; cytoplasmic calpastatin expression had a median H-score of 188 and ranged from 0 to 300 and nuclear calpastatin expression had a median H-score of 54 and ranged from 0 to 300. Here, CAPN2 is linked to pancreatic adenocarcinoma.