CAPN2 and familial pancreatic carcinoma: In pancreatic cancer calpain-2 was significantly associated with overall survival (P = 0.036) (Figure 2, panel A), which remained significant in multivariate Cox-regression analysis (Hazard Ratio (HR) = 0.342; 95% Confidence Interval (95% CI) = 0.157-0.741; P = 0.007) (Table 3 panel A).