The most informative genetic markers of T1D from the list above are HLA-loci, particularly DR4, DR3, DQ, DR2, DR6, and DR7 (Figure 12), as their certain combinations promote the progression of PIFAS as a biopredictor of T1D-related clinical illness at a subclinical stage. This evidence concerns the gene TNFRSF10A and type 1 diabetes mellitus.