Finally, although it is interesting to speculate that there may be differences in galectin-3 expression and related inflammatory changes between C57/B6 G93A SOD1 and SJL SOD1G93A mice that contribute to the overall significantly faster disease progression in the SJL SOD1G93A strain, it is worth noting that the pure SJL/J strain has reduced levels of dysferlin, altered macrophage activity, early functional impairment, and indeed is used as a model of limb girdle muscular dystrophy type 2B (Rayavarapu et al. 2010). This evidence concerns the gene LGALS3 and autosomal recessive limb-girdle muscular dystrophy type 2B.