Altogether, bioinformatic analyses indicated that up-regulation of Cyp7a1 gene expression after 4-wk H-P/C-HF feeding is connected to the enhanced transcriptional activation by FOXO1 and Onecut1 and the reduced transcriptional suppression by NR1I2, NR0B2 and PROX1. The gene discussed is NR0B2; the disease is hydrops fetalis.