Genes associated with apoptosis which were highly regulated in our data set include the apoptosis related serine peptidases (Caspases) which have all been associated with disease in various EAE models [32]; [33] and the toll like receptors 2 and 4 (Tlr2, Tlr4) which have previously been found up-regulated in active lesions of MS and MOG induced EAE in the DA rat [34]; [35]. This evidence concerns the gene TLR4 and myeloid sarcoma.