In an arteriosclerosis model of the apolipoprotein E-knockout (ApoE(−/−)) mouse, administration of WIN reduced macrophageal invasion in plaque lesions, decreased pro-inflammatory gene expression and NF-kappaB activation in aortic tissues and reduced the size of atherosclerotic lesions in the aorta root [58]. This evidence concerns the gene APOE and arteriosclerosis disorder.