The complete calculation of block coevolution for the  peptide provides many insights on this peptide known to be the primary reason of extracellular deposits in Alzheimer's disease [29], [30]:  is a 43 amino acids peptide formed after sequential cleavage of the Amyloid Precursor Protein (APP) and is found in the brain of patients. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.