HMOX1 and type 2 diabetes mellitus: In an earlier study, Bao reported that plasma HO-1 concentrations were significantly increased in newly diagnosed-T2DM cases compared to controls (median (IQR): 2.42 (1.39–3.90) ng/mL in cases vs. 1.11 (0.63–2.06) ng/mL in controls, P<0.001).