Few studies reported that circulating levels of HO-1 were increased in glucose intolerance [17] or T2DM [18] as well as other chronic diseases related to oxidative stress such as silicosis [33], secondary hemophagocytic syndrome (HPS) or adult-onset Still’s disease [34] and Parkinson’s disease [35]. This evidence concerns the gene HMOX1 and type 2 diabetes mellitus.