Of the missense potentially deleterious SNPs higher in prevalence in Qataris compared to at least 1 continent and validated by TaqMan PCR in a larger Qatari population, several were relevant to diseases of high prevalence among Qataris, including genes associated with plasma lipid levels (ACAT2) and diastolic blood pressure (ULK4), as well as a specific SNP associated with type 2 diabetes (UTS2) and a specific SNP associated with nicotine dependence (FMO2). This evidence concerns the gene ACAT2 and nicotine dependence.