Two of these genes have been related to ophthalmologic disorders, including age related macular degeneration (HMCN1) and keratoconus (VSX1) and several have been related to neurologic disorders (IKBKAP, SGCG, SACS, ARHGEF10, and CACNA1S). The gene discussed is SGCG; the disease is age-related macular degeneration.