Because these 4 nsSNPs reside in 3 genes related to estrogen synthesis (HSD17B3, FSHR and CYP19) (Fig. 1), endogenous production of more estrogens, instead of slowing the degradation of estrogens and their metabolites, may be more strongly associated with the risk of endometriosis. The gene discussed is FSHR; the disease is endometriosis.