In regard to the Asn680Ser (A/G) polymorphism of FSHR and the Gly289Ser (G/A) polymorphism of HSD17B3, univariate analyses on all endometriosis women (n = 300) revealed that a combination of homozygous/heterozygous mutants of FSHR (genotype GG+GA, 680Ser/Ser+680Ser/Asn) and homozygous/heterozygous mutants of HSD17B3 (genotype AA+AG, 289Ser/Ser+289Ser/Gly) was associated with significantly decreased risk of endometriosis (P = 0.00002; OR = 0.46) as compared to the combination of homozygous wild types of FSHR and HSD17B3(Table 4). Here, HSD17B3 is linked to endometriosis.