In addition, FSHR with alleles 307Thr/Thr680Asn/Asn (wild-type homozygous) possesses higher bioactivity of intracellular transduction and aromatase after binding to FSH, since women with genotype 307Thr/Thr680Asn/Asn are more likely to develop severe ovarian hyperstimulation syndrome (OHSS) during ovulation induction with FSH [52]. The gene discussed is BRD2; the disease is ovarian hyperstimulation syndrome.