Based on these considerations, we have previously analyzed the possible molecules responsible for the proliferation, invasion and metastasis of cancer cells, and have shown that human head and neck cells in oral squamous and salivary gland carcinomas have a significantly augmented NF-κB activity as compared to their normal counterparts (23,32), suggesting that NF-κB may be an important therapeutic target for the improvement of conventional chemotherapy in oral SCC. This evidence concerns the gene NFKB1 and cancer.