LMNA and Hutchinson-Gilford progeria syndrome: Studies of Hutchison–Gilford progeria syndrome (HGPS) and mutated lamin and proteins interacting with lamins revived and confirmed earlier studies regarding direct and indirect involvement of lamins and lamin containing complexes in chromatin binding and DNA-binding in vivo and its effect on chromatin organization and gene positioning and expression [9, 35, 40, 109, 118, 172, 173].