In addition, the residual tumor epithelial-mesenchymal transition (EMT) was enhanced (N-cadherin and Vimentin were both upregulated, but E-cadherin was downregulated), and this effect could be reversed by Tan IIA (Figures 3A,C, and D, and Additional file 1: Figure S4A). The gene discussed is CDH2; the disease is neoplasm.