However, a direct comparison between the 34% overall impact against AOM in the POET trial (11-valent pneumococcal polysaccharide conjugate vaccine conjugated to H. influenzae-derived protein D [11-Pn-PD]) versus 7% in FinOM (PCV-7) cannot be made due to the different settings and designs of these trials. This evidence concerns the gene DHRS2 and infectious otitis media.