Low production of TNFα is advantageous for the host but its overproduction during infection plays a pivotal role in the development of diseases like disseminated intravascular coagulation, death in septic shock, cerebral malaria, along with wide range of other inflammatory diseases including asthma, dermatitis, multiple sclerosis, inflammatory bowl disease, cystic fibrosis, rheumatoid arthritis, and immunological disorders (Björnsdottir and Cypcar 1999; Murphy et al. 1998; Medana et al. 1997). This evidence concerns the gene TNF and rheumatoid arthritis.