ERBB3 and neoplasm: Next, we investigated the invasive abilities of six NB cell lines using a Matrigel invasion assay to confirm the association of tumor invasiveness with expression of KRT19 and ERBB3. While SK-N-DZ and SK-N-SH cell lines had a low invasive ability (4.12 and 6.75%, respectively), the other cell lines showed a high invasive ability (24.8–62.14%) (Fig. 4).