Moreover, protective tumor-specific T cells recognizing melanoma-derived peptides like tyrosinase-related protein 2 (trp2) and gp100 were induced after immunization of mice with irradiated B78-D14 tumor cells and intact Surek antibody but not with the bsF(ab′)2 counterpart lacking the Fc region [41]. This evidence concerns the gene PMEL and neoplasm.