In addition to the beneficial effects on glucose metabolism, VLDL secretion and hepatic lipid content, GLP-1 receptor agonism also reduces blood pressure and the severity of myocardial infarction, while it concomitantly improves left ventricular ejection fraction after infarction [45], enforcing GLP-1 receptor agonism as a valuable therapy to combat T2DM and associated cardiovascular diseases. Here, GLP1R is linked to type 2 diabetes mellitus.