As the selenoprotein family and selenoprotein biosynthesis pathway are well characterised, the aim of the present study was to investigate the association between SNPs throughout the genes encoding selenoproteins, factors essential for selenocysteine incorporation and related antioxidant proteins, Se status (as assessed by measurement of total serum Se, selenoprotein P (SePP) concentration and serum glutathione peroxidase (GPx3) activity) and prostate cancer risk in a European population with a Se status lower than that found in the USA. Here, SELENOS is linked to Familial prostate cancer.