TXNRD1 and Familial prostate cancer: As shown in Table 4, when analysis was restricted to advanced stage prostate cancer, subjects homozygous for the C allele of rs7310505 in TXNRD1 had an OR of 0.72 (95% CI = 0.56–0.93, p = 0.011) per 10 μg/l increase in serum Se concentration, whereas in subjects carrying the A allele (heterozygous and homozygous) no association was found (pinteraction = 0.02).