CD8A and malaria: In this murine model of malaria, which is widely used for the pre-clinical development of vaccines and drugs, both antibodies to the central repeat domain of CSP and CSP-specific CD8+ T cells have been shown to mediate protection, by inhibiting the migration of sporozoites from the skin to the liver as well as hepatocyte invasion and by hindering the development of parasites within hepatocytes, respectively, thus preventing blood-stage malaria [55], [56], [57], [58].