Regarding the interaction between rs2237892 and BMI on the risk of type 2 diabetes, and the finding that the effect of rs2237892 on diabetes risk was greater for individuals with lower BMI than for those with higher BMI, it is hypothesized that KCNQ1 might participate in the pathogenesis of T2D via non-BMI-mediated pathways [37]. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.