NR3C2 and heart failure: [1] It is well known that aldosterone is a crucial hormone, which regulates electrolyte and volume homeostasis. After binding to mineralocorticoid receptors (MR), aldosterone promotes the retention of sodium and water at the expense of potassium excretion, subsequently resulting in the increase of blood volume and hypertension. Moreover, high aldosterone levels also stimulate synthesis and accumulation of collagens in cardiac fibroblasts leading to MF. The resulting increase in myocardial stiffness thereby causes diastolic dysfunction and ultimately heart failure [2].