CCND1 and colorectal carcinoma: We also studied the relationship between the expression of IgG and that of various biological and prognostic markers in CRC cells, including Bcl-2 (anti-apoptotic protein), Cyclin D1 (proliferation marker), MMP-2 (invasion marker), NF-κB (anti-apoptotic factor and nuclear transcription factor), P53 (tumor suppression gene) and PCNA (proliferation marker).