The changes 2OHOA produces to the structure of the membrane influences the location and activity of amphitropic membrane proteins that are involved in proliferation/differentiation signaling [1], [2], [3], eventually leading to the down-regulation of E2F-1 and dihydrofolate reductase (DHFR), both pivotal proteins in cancer cell proliferation [4], [6]. This evidence concerns the gene DHFR and cancer.