CASP8 and central nervous system cancer: However, this induction of apoptotic features did not fully explain the cell death induced by 2OHOA in 1321N1, SF-767 and U118 glioma cells as we did not observed PARP degradation induction in SF-767 and U118 cells treated with 2OHOA (Fig. 7 E and G), as well as Caspase 8 proteolysis in SF-767 cells (Fig. 7 E).