Given our published data showing replication at FBXO11 across the Raine Study and WAFSOM cohorts [13], and the evidence of others for activation of the transforming growth factor beta (TGFβ) pathway in OM [34], we focused initially on a number of genes that interact within this pathway (Figure S3), including the GALNT14 gene. The gene discussed is FBXO11; the disease is ocular melanoma.